The Role of the Staphylococcus Lugdunensis Isd System in Iron Acquisition and Biofilm Formation
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منابع مشابه
IsdC from Staphylococcus lugdunensis induces biofilm formation in low-iron
33 Staphylococcus lugdunensis is a coagulase-negative Staphylococcus that is a commensal of 34 humans and an opportunistic pathogen. It can cause a spectrum of infections including those that are 35 associated with the ability to form biofilm such as endocarditis or indwelling medical devices. The 36 genome sequences of two strains revealed the presence of orthologues of the ica genes that are ...
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Staphylococcus lugdunensis is a coagulase negative bacterial pathogen that is particularly associated with severe cases of infectious endocarditis. Unique amongst the coagulase-negative staphylococci, S. lugdunensis harbors an iron regulated surface determinant locus (isd). This locus facilitates the acquisition of heme as a source of nutrient iron during infection and allows iron limitation ca...
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Staphylococcus lugdunensis is both a commensal of humans and an opportunistic pathogen. Little is currently known about the molecular mechanisms underpinning the virulence of this bacterium. Here, we demonstrate that in contrast to S. aureus, S. lugdunensis makes neither staphyloferrin A (SA) nor staphyloferrin B (SB) in response to iron deprivation, owing to the absence of the SB gene cluster,...
متن کاملStaphylococcus lugdunensis IsdG liberates iron from host heme.
Staphylococcus lugdunensis is often found as part of the normal flora of human skin but has the potential to cause serious infections even in healthy individuals. It remains unclear what factors enable S. lugdunensis to transition from a skin commensal to an invasive pathogen. Analysis of the complete genome reveals a putative iron-regulated surface determinant (Isd) system encoded within S. lu...
متن کاملIron-regulated surface determinant (Isd) proteins of Staphylococcus lugdunensis.
Staphylococcus lugdunensis is the only coagulase-negative Staphylococcus species with a locus encoding iron-regulated surface determinant (Isd) proteins. In Staphylococcus aureus, the Isd proteins capture heme from hemoglobin and transfer it across the wall to a membrane-bound transporter, which delivers it into the cytoplasm, where heme oxygenases release iron. The Isd proteins of S. lugdunens...
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